Poison Skin Clinic — Glutathione injection badly hospitalised

Glutathione is one of the most important and potent antioxidants. The development of pharmacological compounds that can either increase or decrease glutathione concentrations has allowed investigation into the role of glutathione in various biological processes, including immune responses. Recent findings have shown that glutathione not only affects certain factors involved in immunological processes but also modifies complex immune reactions such as fever. Until recently, it was not known why some patients do not develop fever during infection. Data suggest that fever induction is associated with oxidative stress; therefore, antioxidants such as glutathione can reduce pyrexia. Surprisingly, new studies have shown that low glutathione levels can also inhibit fever. In this review, we focus on recent advances in this area, with an emphasis on the role of glutathione in immune responses accompanied by fever. We describe evidence showing that disturbed glutathione homeostasis may be responsible for the lack of fever during infections. We also discuss the biological significance of the antipyretic effects produced by pharmacological glutathione modulators.
According to a study published in the Epidemiology and Infection journal, patients who received glutathione injections with vitamin C and/or phosphatidylcholine in their infusions were symptomatic within 2 hours of administration with an average duration of illness of 3 days. Most cases reported fever, rigours and headaches 1.
It is important to note that taking glutathione is generally safe and most side effects are mild. However, if you experience redness and swelling after glutathione injections, an ice pack and OTC painkillers may help reduce these symptom.
Sir there is no legit study on why does fever happens after glutathione injections but two things are to be considered:
1) It happens because of elevated oxidative stress post injection…and
2) Fever might be just an immune response and can be treated with any OTC drug.
Sir these are the only studies available online and in the end...

The molecular mechanism of fever still requires more clinical research. Thus, the role of GSH in the mechanism of fever has to be more clearly identified, and additional research is warranted.